Semaphorin 4C accelerates disease progression and enables disease detection in breast cancer

Semaphorins constitute a diverse family of widely expressed transmembrane, diffusible, and GPI-linked proteins with versatile physiologic functions in orchestrating nerve system development, immune homeostasis, angiogenesis, cell metabolism. Accumulating evidence highlights semaphorins as essential regulators tumorigenesis by coordinating the cell-cell communications tumor microenvironment. Semaphorin 4C (SEMA4C) is member fourth class high affinity to Plexin-B2 its interplay cancer has long been significant knowledge gap. Here, this perspective summarizes recent progress understanding SEMA4C comprehensively delineates discovery lymphatic vessels breast cancer, mechanisms which promotes invasiveness, proliferation, metastasis, drug resistance explorations leveraging serum detection, highlighting critical driver progression, an effective biomarker for diagnosis, potential therapeutic target treatment.